Time: Wednesday, July 28, 9:00 am - noon
Place: Bioinformatics Computer Core Lab (Rm 104), Life Sciences Bldg
Organizers: Michael Miles
Audience: Primarily 1st year students

Topics of session

• Why microarrays?
• History of study of gene regulation and expression analysis
• Steps in expression analysis
• Sources of variability
• Example: Search for baldness cure (see Problem Set 1)

Resources of session

Required Reading:
• Daniel H. Geschwind, MD, PhD; Joseph D. Dougherty; Lili C. Kudo; Stanislav Karsten. Beyond The Gene List: Using Bioinformatics To Make Sense Out Of Array Data.
• Michael F. Miles, M.D., Ph.D. and Robnet Kerns, Ph.D. Analysis and Interpretation of Microarray Data. Department of Pharmacology and Toxicology. Virginia Commonwealth University Richmond, VA

Optional Reading:
• Article: Quackenbush (2000): Computational Analysis of Microarray Data. Nature Reviews Genetics 2:418-427 [HTML]
  Excellent in terms of explaining analysis issues/approaches
• Article: Teferri A, et al (2002): Primer on Medical Genomics, Part III: Microarray Experiments and Data Analysis. Mayo Clin Proc. 77:927-940. [PDF]
  Good general review of microarrays and data analysis
• Article: NCBI (2003): A Science Primer: Microarrays -- Chipping Away at the Mysteries of Science and Medicine. [HTML]
  Short and basic


Additional Resources
• Link: TIGR Microarray Resources
  Check out the Microarrays Overview, a very nice PowerPoint presentation that gives a visual feel for how microarrays are made and used (unfortunately in PDF format and minus the presenter).
• Presentation: BBSIleccture7_04.ppt - PowerPoint slides we will use in class.
• Data: BBSIarraydata7_04.xls - data set we are going to use in class.

Before coming to the session

• Look over the Problem Set 1.
• Read the required articles listed above and if you have time look over the optional material.
• Download the data set and have MS Excel open.

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