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VCU BBSI Closing Symposium 2003
Estimating energy changes produced by mutations in the U1A protein complex
Peter Likarish, 2:15 pm
I will discuss the various trials and tribulations associated with altering an
experimentally determined model of a protein-rna interaction so that it can be
used to predict the change in energy associated with single/double monomer
mutations in the U1A protein. I will specifically address using the HINT
program, developed by Glen Kellogg, to calculate the energy change.
Rather than approaching the problem of a protein-RNA interaction as an
exhaustive molecular mechanics model, HINT attempts to concentrate on the
aspects of the system that actually contribute to the energy change, resulting
in a much less computationally expensive procedure for determining the change
in energy. My research this summer has focused on developing potential
protocols to insure reproducible, accurate results.
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