|
The origin of human genetic variability from
cross-species comparisons: The truth about Blast
Trust but verify
Your first thought is to confirm the locations in chimp chromosome 22 corresponding to her three SNPs. You Blast the three SNPs against the chromosome and arrive at the results shown. Thus armed, you report back to your colleague that while two of her human SNPs indeed match sequences in chimp chromosome 22, one evidently does not. Regretably, she must be in error. |
RS968436: GGGCGGGGARCCTGGCCACCA
44142739: GGGCGGGGAGCCTGGCCACCA
RS1059610: GGGGCTTYTGAGCACGGGCTC
47302514: GGGGCTTCCGAGCACGGGCTC
RS1140646: AGCACCGCCGMGGACTCCAGC
No hit in chimp chromosome 22
Blast comparison of human SNPs (identified by RS#s) to chimpanzee chromosome 22 sequence (coordinates shown). |
In approximately 47 milliseconds you get back her response that RS1140646 most certainly can be found in chromosome 22, plus the additional hypothesis that perhaps your program couldn't tell an adenine from an adenoid.
How could this be?
Back to main Scenario page back one page continue
|
