Introduction to functional genomics: DNA microarray platforms and methods

Topics

• Why microarrays?
• History of study of gene regulation and expression analysis
• Steps in expression analysis
• Sources of variability
• Example: Search for baldness cure (see Problem Set)

• Article: Quackenbush (2000): Computational Analysis of Microarray Data. Nature Reviews Genetics 2:418-427 [HTML]
  Excellent in terms of explaining analysis issues/approaches
• Article: Teferri A, et al (2002): Primer on Medical Genomics, Part III: Microarray Experiments and Data Analysis. Mayo Clin Proc. 77:927-940. [PDF]
  Good general review of microarrays and data analysis
• Article: NCBI (2003): A Science Primer: Microarrays -- Chipping Away at the Mysteries of Science and Medicine. [HTML]
  Short and basic
• Link: TIGR Microarray Resources
  Check out the Microarrays Overview, a very nice PowerPoint presentation that gives a visual feel for how microarrays are made and used (unfortunately in PDF format and minus the presenter).
• Presentation: [PPS - runs independent of PowerPoint] or [PPT]
• Data

Back to Research Simulation Main Page