Applications of PSSMs

Topics

• Regulatory protein and their binding sites
• Meme and Gibbs Sampler
• Discussion of Li et al (2002)

• Notes and Study Questions
  See end of notes for portion of article to focus on
• Paper: Li et al (2002) Identification of the binding sites of regulatory proteins in bacterial genomes
• Data: cAMP-related protein (for Meme, Problem E1)
• Questionnaire

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