VCU Bioinformatics and Bioengineering Summer Institute
Virginia Commonwealth University
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Research Simulation Scenario
Phage sequences in bacterial genomes
The truth behind Blast

Explaining pathogenesis

Yes. They are not matches, are they. That's all right, not everything has to match, does it? Still, maybe it would be better if BLAST sits in a corner and calculates some square roots while we talk.

You began with the desire to understand the basis of bacterial pathogenesis. Now you're confronted with the problem of explaining a pathological computer program. But...

HOW CAN THIS BE???

BLAST is the most widely used bioinformatic program in the world! How could it get scrambled by a crummy 20 nucleotide sequence?

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