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The origin of human genetic variability from
cross-species comparisons: The truth about Blast
What in the name of Watsonandcrick is going on around here???
You began with the desire to understand the basis of variability in human genome sequences. Now you're confronted with the problem of explaining variability in a computer program, why it finds some matches but not others. And not just any computer program...
...Blast is the most widely used bioinformatic program in the world! How could it get scrambled by a crummy 21-nucleotide sequence?
How can you explain Blast's failure to find an obvious match?
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