Jennifer S. Wayne

McGuire Hall Annex, Room 325   Dept. of Biomedical Engineering   Virginia Commonwealth University   1112 E. Clay St.   Richmond, VA 23298-0694	Tel: 804-828-2595 Fax: 804-828-4454 E-mail: jwayne@vcu.edu
Web: www.people.vcu.edu/~jwayne/jwayne.htm
Research: Cartilage repair and computational modeling of tissue

BBSI project: Cartilage repair — can it be accomplished?

Unlike many tissues in our body, articular cartilage appears to have a limited ability to heal itself once injured. The damage to cartilage continues to progress with significant pain and dysfunction resulting for the affected joint. How can we intervene to arrest the progressive damage and restore normal function to the joint surface? Can we use computational modeling tools to help us predict the success of our approach(es)?

References
Wayne JS, Kraft KA, Shields KJ, Yin C, Owen JR, Disler DG: MR imaging of normal and matrix depleted cartilage - Correlation with biomechanical function and biochemical composition. Radiology, 228:493-499, 2003.

Wayne JS, McDowell CL, Willis MC: Long-term survival of regenerated cartilage on a large joint surface. Journal of Rehabilitation Research and Development, 38(2):191-200, 2001.

Mukherjee N, Wayne JS: Load sharing between solid and fluid phases in articular cartilage - II. Comparison of experimental results and u-p finite element predictions. Journal of Biomechanical Engineering, 120:614-619, 1998.

Other research interests (see web page for more details)

Function of Articular Cartilage
Ligament and Tendon Mechanics
Biomechanics of Joints
Structural Stability of Fixation Constructs

Other projects:
Finite element analyses of articular cartilage behavior
Tissue engineering of articular cartilage
Reparative approaches for damaged articular surfaces
Correlation of cartilage function with MRI characteristics
Characterization of new materials for biomedical applications
Evaluating the tendon/suture interface

close window