VCU Bioinformatics and Bioengineering Summer Institute
Virginia Commonwealth University

Gary L. Bowlin

  McGuire Hall Annex, Room 119 A
  Dept. of Biomedical Engineering
  1112 E. Clay St., Suite 220
  Virginia Commonwealth University
  Richmond, VA 23298-0694

 Tel: 804-828-2592
Fax: 804-828-4454
E-mail: glbowlin@vcu.edu
  Web: www.people.vcu.edu/~glbowlin/
  Research:   engineering vascular tissue

BBSI project: Does Fiber Diameter Alter MMP-1 Production on Electrospun Poly (glycolic acid)?

This research project will evaluate novel tissue engineering scaffolds composed of poly (glycolic acid) (PGA) nanofibers produced by electrospinning to determine if dependence exists between fiber diameter (100 - 1,000 nm) and mesenchymal cell expression of MMP-1. This project will combine nanotechnology, engineering, and biochemistry.

References
Boland ED, Wnek GE, Simpson DG, Pawlowski KJ, Bowlin GL (2001).
Tailoring tissue engineering scaffolds using electrostatic processing techniques: A study of poly(glycolic acid) electrospinning. J Macromol Sci - Pure Appl Chem A38:1231-1243.

Matthews JA, Wnek GE, Simpson DG, Bowlin GL (2002).
Electrospinning of Collagen Nanofibers. Biomacromolecules 3:232-238.

Other research interests (see web page for more details)

The primary research emphasis in the Tissue Engineering Laboratory is the development of a small diameter vascular prosthetic. Other research interests include.

  • Electrostatic Endothelial Cell Transplantation
  • Small Diameter Vascular Prostheses and Endovascular Grafts
  • Intravascular Stents
  • Simultaneous Electrostatic Endothelial Cell Transplantation/Transfection
  • Small Diameter Vascular Prostheses
  • Intravascular Stents
  • Gene Therapy
  • In Vivo Insulin Delivery System
  • Development of a Small Diameter Biomimicking (Tissue Engineered) Vascular Prosthesis
  • Muscle Tissue Engineering (Skeletal and Cardiac)
  • Novel Production of Tissue Engineering Scaffolds (< 10 micron fibers and/or beads)
  • Small Diameter Vascular Grafts
  • Muscle Implants
  • Nerve Guides
  • Tissue-Based Biosensor
  • Biological/Chemical Warfare Agent Detection
  • Determine Industrial Chemical Exposure Limits

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