Summit on Systems Biology
June 16-19, 2009 (Richmond VA)

Tuesday, June 16

6 – 8pm Registration at the Omni Hotel

Wednesday, June 17

7:45am Continental Breakfast and Registration

8:45am Welcoming Remarks

Session I: Microbial Engineering

9:00am Plenary Speaker: Kristala Prather, MIT: Rational Design of Microbial Chemical Factories

10:00am Jingdong Tian, Duke University: Enabling Effective Design, Construction and Optimization of Synthetic Biosystems

10:25am Break

10:35am Speaker

11:00am Plenary Speaker: Christina Smolke, Stanford University: Advancing Synthetic Metabolic Network Design Through Embedded Sensing-Actuation Devices

12:00pm Lunch at the Omni Hotel

1:00pm Keynote Speaker: James Collins, Boston University: Engineering Microbial Gene Networks: Integrating Synthetic Biology and Systems Biology

Session II: Modeling Microbial Systems

2:00pm Plenary Speaker: Jean Peccoud, Virginia Tech: An Engineering Approach to Characterizing Structure-Function Relationship in DNA Sequences

3:00pm Break

3:15pm Christopher Gowen, VCU: Genome-Scale Constraint-Based Metabolic Models as Tools for Engineering Cellulosic Biofuel Production

3:40pm Hao Song, Duke University: Spatiotemporal Modulation of Biodiversity in a Synthetic Chemical-Mediated Ecosystem

4:05pm Seth Roberts, VCU: Proteomic and Network Analysis Characterize Stage-Specific Metabolism in Trypanosoma cruzi

4:30pm Ping Xu, VCU: Biofilm Gene Association in Oral Streptococci by Systems Biology

6:30pm Gala Dinner at the Omni Hotel

Thursday, June 18

7:45am Continental Breakfast

Session III: Host-Pathogen Interactions

8:30am Plenary Speaker: James Musser, The Methodist Hospital, Houston, Texas: New Understanding of Group A Streptococcus Pathogenesis Provided by Integrated Systems Biology Studies

9:30am Candice Johnson, Meharry Medical College: Gene Network Analysis During Early Cellular Infection by Trypanosoma cruzi

9:55am Shlomo Ta'asan Carnegie Mellon University: A Mathematical Approach for Understanding Host-Pathogen Interactions

10:20am Break

10:35am Plenary Speaker: Cammie Lesser, Harvard University: Yeast Functional Genomic Approaches Provide New Insights into How Human Bacterial Pathogens Cause Disease

11:35am Alison Criss, University of Virginia: Disarming of Host Neutrophil Defenses by Neisseria gonorrhoeae

12:00pm Lunch at the Omni Hotel

1:00pm Isabel Santos, University of São Paulo-Riberão Preto, Brazil: Transcriptional Profiles of Tick-Infested Skin and Tick Salivary Glands in Contrasting Phenotypes of Tick-Host Interfaces Reveal Patterns that are Associated with Resistance to Ticks

1:25pm Judith Klein-Seetharaman, Carnegie Mellon University: Identification of Alternative Routes Circumventing HIV-1 Targeted Pathways in Human Signal Transduction Networks

1:50pm Keynote Speaker: David Botstein, Princeton University: Coordination of Growth Rate, Cell Cycle, Stress Response and Metabolic Activity in Yeast

2:50pm Break

Session IV: Human Microbiome

3:05pm Plenary Speaker: Jeremy Nicholson, Imperial College London: Top-Down Systems Biology of Metabolic Supersystems: from Personalized Healthcare to Molecular Epidemiology

4:05pm Patrick Gillevet, George Mason University: The Human Metabiome: Correlating the Human Microbiome with Disease

4:30pm Huzefa Rangwala, George Mason University: Disease Inference using Microbiome Informatics

4:55pm Break

5:10pm Plenary Speaker: Michelle Giglio, University of Maryland: A Data Analysis and Coordination Center for the Human Microbiome Project

6:30pm Heavy hors d'ouevres and Poster Session

7:45pm Technology Workshop

Friday, June 19

7:45am Continental Breakfast

Session V: Technological Advances in Systems Biology

8:30am Plenary Speaker: Yuan Gao, VCU: Transforming Basic and Translational Research by Next-Generation Sequencing

9:30am Speaker

9:55am Dan Sullivan, Virginia Tech: Data Integration for Dynamic and Sustainable Systems Biology Resources: Challenges and Lessons

10:20am Break

10:35am Keynote Speaker: John Yates, Scripps Institute: Driving Biological Discovery using Quantitative Mass Spectrometry

11:35am Lunch at the Omni Hotel

1:00pm Workshops

The Microbial Tree of Life

1:00pm Plenary Speaker: Mark Farmer, University of Georgia: Re-rooting the Tree of Life

2:00pm Maria Rivera, VCU

2:30pm Break

2:50pm Danail Bonchev, VCU: Evolution of Metabolic Networks Organization

3:20pm Jeff Elhai, VCU: Biobike: Providing Biologists without Programming Experience Creative Control over the Analysis of Bioinformation

3:50pm Plenary Speaker: Richard. Triemer, Michigan State University: Phylogeny of Photosynthetic Euglenoids – What Have We Learned?

Gene Networks and Disease

1:00pm Plenary Speaker: Mark Gerstein, Yale University: Understanding Protein Function on a Genome-scale using Networks

2:00pm Bing Zhang, Vanderbilt University: Network Approaches to Elucidate the Molecular Basis of Disease

2:25pm Victor Jin, Ohio State University: Dissecting Hierarchical Regulatory Network of Estrogen-Dependent Breast Cancer through an Integrative Genomic Analysis

2:50pm Break

3:05pm Soumya Raychaudhuri, Broad Institute: A Text-Based Strategy to Identify Disease Variants: Looking for Gene Relationships Across Implicated Loci (GRAIL)

3:30pm Nathan Menke, VCU: Fuzzy Modularity of Biological Networks

3:55pm Ali Abdi, New Jersey Institute of Technology: Fault Diagnosis Engineering in Molecular Signaling Networks

4:20pm Jingchun Sun, VCU: A Comparative Study of Schizophrenia and Cancer Gene Network Properties