// Metabolic Reactions // -1.0000000 GLC -1.0000000 ATP +1.0000000 G6P +1.0000000 ADP 0 GLK1 -1.0000000 G6P +1.0000000 F6P 0 PGI1R -1.0000000 bDG6P +1.0000000 G6P 0 PGI2R -1.0000000 bDG6P +1.0000000 F6P 0 PGI3R -1.0000000 bDGLC +1.0000000 GLC 0 GALMR -1.0000000 G1P +1.0000000 GLC +1.0000000 PI 0 AGP -1.0000000 F6P -1.0000000 ATP +1.0000000 FDP +1.0000000 ADP 0 PFKA -1.0000000 F6P -1.0000000 ATP +1.0000000 FDP +1.0000000 ADP 0 PFKB1 -1.0000000 FDP +1.0000000 F6P +1.0000000 PI 0 FBP -1.0000000 FDP +1.0000000 T3P1 +1.0000000 T3P2 0 FBAR -1.0000000 T3P1 +1.0000000 T3P2 0 TPIAR -1.0000000 T3P1 -1.0000000 PI -1.0000000 NAD +1.0000000 NADH +1.0000000 13PDG 0 GAPAR -1.0000000 T3P1 -1.0000000 PI -1.0000000 NAD +1.0000000 NADH +1.0000000 13PDG 0 GAPCR -1.0000000 13PDG -1.0000000 ADP +1.0000000 3PG +1.0000000 ATP 0 PGKR -1.0000000 3PG +1.0000000 2PG 0 GPMAR -1.0000000 3PG +1.0000000 2PG 0 GPMBR -1.0000000 2PG +1.0000000 PEP 0 ENOR -1.0000000 PYR -1.0000000 ATP +1.0000000 PEP +1.0000000 AMP +1.0000000 PI 0 PPSA -1.0000000 PEP -1.0000000 ADP +1.0000000 PYR +1.0000000 ATP 0 PYKA -1.0000000 PEP -1.0000000 ADP +1.0000000 PYR +1.0000000 ATP 0 PYKF -1.0000000 PYR -1.0000000 COA -1.0000000 NAD +1.0000000 NADH +1.0000000 CO2 +1.0000000 ACCOA 0 ACEE -1.0000000 ATP -1.0000000 G1P +1.0000000 ADPGLC +1.0000000 PPI 0 GLGC -1.0000000 ADPGLC +1.0000000 ADP +1.0000000 GLYCOGEN 0 GLGA -1.0000000 GLYCOGEN -1.0000000 PI +1.0000000 G1P 0 GLGP -1.0000000 GLYCOGEN -1.0000000 PI +1.0000000 G1P 0 MALP -1.0000000 G6P -1.0000000 NADP +1.0000000 D6PGL +1.0000000 NADPH 0 ZWFR -1.0000000 D6PGL +1.0000000 D6PGC 0 PGL -1.0000000 D6PGC -1.0000000 NADP +1.0000000 NADPH +1.0000000 CO2 +1.0000000 RL5P 0 GND -1.0000000 RL5P +1.0000000 R5P 0 RPIAR -1.0000000 RL5P +1.0000000 R5P 0 RPIBR -1.0000000 RL5P +1.0000000 X5P 0 RPER -1.0000000 R5P -1.0000000 X5P +1.0000000 T3P1 +1.0000000 S7P 0 TKTA1R -1.0000000 R5P -1.0000000 X5P +1.0000000 T3P1 +1.0000000 S7P 0 TKTB1R -1.0000000 X5P -1.0000000 E4P +1.0000000 F6P +1.0000000 T3P1 0 TKTA2R -1.0000000 X5P -1.0000000 E4P +1.0000000 F6P +1.0000000 T3P1 0 TKTB2R -1.0000000 T3P1 -1.0000000 S7P +1.0000000 E4P +1.0000000 F6P 0 TALBR -1.0000000 D6PGC +1.0000000 2KD6PG 0 EDD -1.0000000 2KD6PG +1.0000000 T3P1 +1.0000000 PYR 0 EDA -1.0000000 ACCOA -1.0000000 OA +1.0000000 COA +1.0000000 CIT 0 GLTA -1.0000000 CIT +1.0000000 ICIT 0 ACNAR -1.0000000 CIT +1.0000000 ICIT 0 ACNBR -1.0000000 ICIT -1.0000000 NADP +1.0000000 CO2 +1.0000000 NADPH +1.0000000 AKG 0 ICDAR -1.0000000 AKG -1.0000000 NAD -1.0000000 COA +1.0000000 CO2 +1.0000000 NADH +1.0000000 SUCCOA 0 SUCA -1.0000000 SUCCOA -1.0000000 ADP -1.0000000 PI +1.0000000 ATP +1.0000000 COA +1.0000000 SUCC 0 SUCCR -1.0000000 SUCC -1.0000000 FAD +1.0000000 FADH +1.0000000 FUM 0 SDHA1 -1.0000000 FUM -1.0000000 FADH +1.0000000 SUCC +1.0000000 FAD 0 FRDA -1.0000000 FUM +1.0000000 MAL 0 FUMAR -1.0000000 FUM +1.0000000 MAL 0 FUMBR -1.0000000 FUM +1.0000000 MAL 0 FUMCR -1.0000000 MAL -1.0000000 NAD +1.0000000 NADH +1.0000000 OA 0 MDHR -1.0000000 PYR -1.0000000 NADH +1.0000000 NAD +1.0000000 LAC 0 DLD1R -1.0000000 PYR -1.0000000 NADH +1.0000000 NAD +1.0000000 LAC 0 LDHAR -1.0000000 ACCOA -2.0000000 NADH +1.0000000 ETH +2.0000000 NAD +1.0000000 COA 0 ADHE2R -1.0000000 PYR -1.0000000 COA +1.0000000 ACCOA +1.0000000 FOR 0 PFLA -1.0000000 PYR -1.0000000 COA +1.0000000 ACCOA +1.0000000 FOR 0 PFLC -1.0000000 FOR +1.0000000 CO2 0 FDHF1 -1.0000000 ACCOA -1.0000000 PI +1.0000000 ACTP +1.0000000 COA 0 PTAR -1.0000000 ACTP -1.0000000 ADP +1.0000000 ATP +1.0000000 AC 0 ACKAR -1.0000000 ACTP -1.0000000 ADP +1.0000000 ATP +1.0000000 AC 0 PURT1R -1.0000000 ATP -1.0000000 AC -1.0000000 COA +1.0000000 AMP +1.0000000 PPI +1.0000000 ACCOA 0 ACS -1.0000000 OA -1.0000000 ATP +1.0000000 PEP +1.0000000 CO2 +1.0000000 ADP 0 PCKA -1.0000000 PEP -1.0000000 CO2 +1.0000000 OA +1.0000000 PI 0 PPC -1.0000000 MAL -1.0000000 NADP +1.0000000 CO2 +1.0000000 NADPH +1.0000000 PYR 0 MAEB -1.0000000 MAL -1.0000000 NAD +1.0000000 CO2 +1.0000000 NADH +1.0000000 PYR 0 SFCA -1.0000000 ICIT +1.0000000 GLX +1.0000000 SUCC 0 ACEA -1.0000000 ACCOA -1.0000000 GLX +1.0000000 COA +1.0000000 MAL 0 ACEB -1.0000000 ACCOA -1.0000000 GLX +1.0000000 COA +1.0000000 MAL 0 GLCB -1.0000000 PPI +2.0000000 PI 0 PPA -1.0000000 NADH -1.0000000 Q +1.0000000 NAD +1.0000000 QH2 0 NDH -1.0000000 NADH -1.0000000 Q +1.0000000 NAD +1.0000000 QH2 +3.5000000 HEXT 0 NUOA -1.0000000 FOR -1.0000000 Q +1.0000000 QH2 +1.0000000 CO2 +2.0000000 HEXT 0 FDNG -1.0000000 FOR -1.0000000 Q +1.0000000 QH2 +1.0000000 CO2 +2.0000000 HEXT 0 FDOH -1.0000000 FOR -1.0000000 Q +1.0000000 QH2 +1.0000000 CO2 +2.0000000 HEXT 0 FDHF2 -1.0000000 PYR -1.0000000 Q +1.0000000 AC +1.0000000 CO2 +1.0000000 QH2 0 POXB -1.0000000 LAC -1.0000000 Q +1.0000000 PYR +1.0000000 QH2 0 DLD2 -1.0000000 GL3P -1.0000000 Q +1.0000000 T3P2 +1.0000000 QH2 0 GLPD -1.0000000 GL3P -1.0000000 Q +1.0000000 T3P2 +1.0000000 QH2 0 GLPA -1.0000000 QH2 -0.5000000 O2 +1.0000000 Q +2.5000000 HEXT 0 CYOA -1.0000000 QH2 -0.5000000 O2 +1.0000000 Q +2.0000000 HEXT 0 CYDA -1.0000000 FADH -1.0000000 Q +1.0000000 FAD +1.0000000 QH2 0 SDHA2R -1.0000000 OTHIO -1.0000000 NADPH +1.0000000 NADP +1.0000000 RTHIO 0 TRXB -1.0000000 NADPH -1.0000000 NAD +1.0000000 NADP +1.0000000 NADH +.5 HEXT 0 PNT1A -1.0000000 NADP -1.0000000 NADH -2.0000000 HEXT +1.0000000 NADPH +1.0000000 NAD 0 PNT2A -2.0000000 HEXT +2.0000000 QH2 +1.0000000 H2 0 HYAAR -2.0000000 HEXT +2.0000000 QH2 +1.0000000 H2 0 HYBAR -2.0000000 HEXT +2.0000000 QH2 +1.0000000 H2 0 HYCFR // ATPase Reaction // // I have reversed the stoichiometry for the PhPP analysis // +1.0000000 ATP -1.0000000 ADP -1.0000000 PI -4.0000000 HEXT 0 ATPAR -1.0000000 MELI +1.0000000 GLC +1.0000000 GLAC 0 MELA -1.0000000 GLAC -1.0000000 ATP +1.0000000 GAL1P +1.0000000 ADP 0 GALK -1.0000000 GAL1P -1.0000000 UDPG +1.0000000 G1P +1.0000000 UDPGAL 0 GALTR -1.0000000 UDPGAL +1.0000000 UDPG 0 GALER -1.0000000 G1P -1.0000000 UTP +1.0000000 UDPG +1.0000000 PPI 0 GALU1R -1.0000000 G1P +1.0000000 G6P 0 PGMR -1.0000000 LCTS +1.0000000 GLC +1.0000000 GLAC 0 BGLX -1.0000000 LCTS +1.0000000 GLC +1.0000000 GLAC 0 LACZ -1.0000000 TRE6P +1.0000000 bDG6P +1.0000000 GLC 0 TREC -1.0000000 SUC6P +1.0000000 G6P +1.0000000 FRU 0 FRCTDS -1.0000000 F1P -1.0000000 ATP +1.0000000 FDP +1.0000000 ADP 0 FRUK1 -1.0000000 FRU +1.0000000 GLC 0 XYLA1 -1.0000000 MAN6P +1.0000000 MAN1P 0 CPSGR -1.0000000 MAN1P +1.0000000 F6P 0 MANAR -1.0000000 NAGP +1.0000000 GA6P +1.0000000 AC 0 NAGA -1.0000000 GA6P +1.0000000 F6P +1.0000000 NH3 0 NAGB -1.0000000 SLA +1.0000000 PYR +1.0000000 NAMAN 0 NANA -1.0000000 FUC +1.0000000 FCL 0 FUCIR -1.0000000 FCL -1.0000000 ATP +1.0000000 FCL1P +1.0000000 ADP 0 FUCK -1.0000000 FCL1P +1.0000000 LACAL +1.0000000 T3P2 0 FUCAR -1.0000000 LACAL -1.0000000 NADH +1.0000000 12PPD +1.0000000 NAD 0 FUCOR -1.0000000 LACAL -1.0000000 NAD +1.0000000 LLAC +1.0000000 NADH 0 ALDAR -1.0000000 LACAL -1.0000000 NAD +1.0000000 LLAC +1.0000000 NADH 0 ALDBR -1.0000000 LACAL -1.0000000 NAD +1.0000000 LLAC +1.0000000 NADH 0 ADHC1R -1.0000000 GLAL -1.0000000 NADH +1.0000000 GL +1.0000000 NAD 0 ADHC2R -1.0000000 LACAL -1.0000000 NAD +1.0000000 LLAC +1.0000000 NADH 0 ADHE1 -1.0000000 LACAL -1.0000000 NAD +1.0000000 LLAC +1.0000000 NADH 0 ALDH1R -1.0000000 ACAL -1.0000000 NAD +1.0000000 AC +1.0000000 NADH 0 ALDH2 -1.0000000 GLCN -1.0000000 ATP +1.0000000 D6PGC +1.0000000 ADP 0 GNTV -1.0000000 GLCN -1.0000000 ATP +1.0000000 D6PGC +1.0000000 ADP 0 GNTK -1.0000000 RMN +1.0000000 RML 0 RHAAR -1.0000000 RML -1.0000000 ATP +1.0000000 RML1P +1.0000000 ADP 0 RHAB -1.0000000 RML1P +1.0000000 LACAL +1.0000000 T3P2 0 RHADR -1.0000000 ARAB +1.0000000 RBL 0 ARAAR -1.0000000 RL5P +1.0000000 A5P 0 A5PISOR -1.0000000 RBL -1.0000000 ATP +1.0000000 RL5P +1.0000000 ADP 0 ARAB -1.0000000 RL5P +1.0000000 X5P 0 ARADR -1.0000000 XYL +1.0000000 XUL 0 XYLA2R -1.0000000 XUL -1.0000000 ATP +1.0000000 X5P +1.0000000 ADP 0 XYLB -1.0000000 RIB -1.0000000 ATP +1.0000000 R5P +1.0000000 ADP 0 RBSK -1.0000000 MNT6P -1.0000000 NAD +1.0000000 F6P +1.0000000 NADH 0 MTLDR -1.0000000 GLT6P -1.0000000 NAD +1.0000000 F6P +1.0000000 NADH 0 SRLDR -1.0000000 GLTL1P -1.0000000 NAD +1.0000000 TAG6P +1.0000000 NADH 0 GATDR -1.0000000 TAG6P -1.0000000 ATP +1.0000000 TAG16P +1.0000000 ADP 0 PFKB2 -1.0000000 TAG6P -1.0000000 ATP +1.0000000 TAG16P +1.0000000 ADP 0 FRUK2 -1.0000000 TAG6P -1.0000000 ATP +1.0000000 TAG16P +1.0000000 ADP 0 AGAZ -1.0000000 TAG16P +1.0000000 T3P2 +1.0000000 T3P1 0 GATZR -1.0000000 TAG16P +1.0000000 T3P2 +1.0000000 T3P1 0 AGAYR -1.0000000 GL -1.0000000 ATP +1.0000000 GL3P +1.0000000 ADP 0 GLPK -1.0000000 GL3P -1.0000000 NADP +1.0000000 T3P2 +1.0000000 NADPH 0 GPSA1R -1.0000000 DR1P +1.0000000 DR5P 0 DEOB1R -1.0000000 R1P +1.0000000 R5P 0 DEOB2R -1.0000000 DR5P +1.0000000 ACAL +1.0000000 T3P1 0 DEOC -1.0000000 OA -1.0000000 GLU +1.0000000 ASP +1.0000000 AKG 0 ASPC1R -1.0000000 ASP -1.0000000 ATP -1.0000000 GLN +1.0000000 GLU +1.0000000 ASN +1.0000000 AMP +1.0000000 PPI 0 ASNB1 -1.0000000 ASP -1.0000000 ATP -1.0000000 NH3 +1.0000000 ASN +1.0000000 AMP +1.0000000 PPI 0 ASNA1 -1.0000000 AKG -1.0000000 NH3 -1.0000000 NADPH +1.0000000 GLU +1.0000000 NADP 0 GDHAR -1.0000000 GLU -1.0000000 NH3 -1.0000000 ATP +1.0000000 GLN +1.0000000 ADP +1.0000000 PI 0 GLNA -1.0000000 AKG -1.0000000 GLN -1.0000000 NADPH +1.0000000 NADP +2.0000000 GLU 0 GLTB -1.0000000 PYR -1.0000000 GLU +1.0000000 AKG +1.0000000 ALA 0 ALABR -1.0000000 OIVAL -1.0000000 ALA +1.0000000 PYR +1.0000000 VAL 0 AVTA1 -1.0000000 ALA +1.0000000 DALA 0 ALR_R -1.0000000 ALA +1.0000000 DALA 0 DADX -1.0000000 GLU -1.0000000 ACCOA +1.0000000 COA +1.0000000 NAGLU 0 ARGA -1.0000000 NAGLU -1.0000000 ATP +1.0000000 ADP +1.0000000 NAGLUYP 0 ARGB -1.0000000 NAGLUYP -1.0000000 NADPH +1.0000000 NADP +1.0000000 PI +1.0000000 NAGLUSAL 0 ARGCR -1.0000000 NAGLUSAL -1.0000000 GLU +1.0000000 AKG +1.0000000 NAARON 0 ARGDR -1.0000000 NAARON +1.0000000 AC +1.0000000 ORN 0 ARGE1 -1.0000000 GLN -2.0000000 ATP -1.0000000 CO2 +1.0000000 GLU +1.0000000 CAP +2.0000000 ADP +1.0000000 PI 0 CARA -1.0000000 ORN -1.0000000 CAP +1.0000000 CITR +1.0000000 PI 0 ARGFR -1.0000000 ORN -1.0000000 CAP +1.0000000 CITR +1.0000000 PI 0 ARGIR -1.0000000 ORN -1.0000000 AKG +1.0000000 GLUGSAL +1.0000000 GLU 0 YGJG -1.0000000 CITR -1.0000000 ASP -1.0000000 ATP +1.0000000 AMP +1.0000000 PPI +1.0000000 ARGSUCC 0 ARGG -1.0000000 ARGSUCC +1.0000000 FUM +1.0000000 ARG 0 ARGHR -1.0000000 ARG +1.0000000 CO2 +1.0000000 AGM 0 SPEA -1.0000000 ARG +1.0000000 CO2 +1.0000000 AGM 0 ADI -1.0000000 AGM +1.0000000 UREA +1.0000000 PTRC 0 SPEB -1.0000000 ORN +1.0000000 PTRC +1.0000000 CO2 0 SPEC -1.0000000 ORN +1.0000000 PTRC +1.0000000 CO2 0 SPEF -1.0000000 SAM +1.0000000 DSAM +1.0000000 CO2 0 SPEDR -1.0000000 PTRC -1.0000000 DSAM +1.0000000 SPMD +1.0000000 5MTA 0 SPEE -1.0000000 5MTA +1.0000000 AD +1.0000000 5MTR 0 MTHAKN -1.0000000 5MTR -1.0000000 ATP +1.0000000 5MTRP +1.0000000 ADP 0 MTHRKN -1.0000000 5MTRP +1.0000000 5MTR1P 0 MTHIPISR -1.0000000 5MTR1P +1.0000000 DKMPP 0 NE1PH -1.0000000 DKMPP +1.0000000 FOR +1.0000000 KMB 0 NE3UNK -1.0000000 KMB -1.0000000 GLN +1.0000000 GLU +1.0000000 MET 0 TNSUNK -1.0000000 GLU -1.0000000 ATP +1.0000000 ADP +1.0000000 GLUP 0 PROB -1.0000000 GLUP -1.0000000 NADPH +1.0000000 NADP +1.0000000 PI +1.0000000 GLUGSAL 0 PROA -1.0000000 NAGLUSAL +1.0000000 GLUGSAL +1.0000000 AC 0 ARGE2 -1.0000000 GLUGSAL -1.0000000 NADPH +1.0000000 PRO +1.0000000 NADP 0 PROC -1.0000000 THR +1.0000000 NH3 +1.0000000 OBUT 0 ILVA -1.0000000 THR +1.0000000 NH3 +1.0000000 OBUT 0 TDCB1 -1.0000000 OBUT -1.0000000 PYR +1.0000000 ABUT +1.0000000 CO2 0 ILVB1 -1.0000000 OBUT -1.0000000 PYR +1.0000000 ABUT +1.0000000 CO2 0 ILVG1 -1.0000000 OBUT -1.0000000 PYR +1.0000000 ABUT +1.0000000 CO2 0 ILVI1 -1.0000000 ABUT -1.0000000 NADPH +1.0000000 NADP +1.0000000 DHMVA 0 ILVC1 -1.0000000 DHMVA +1.0000000 OMVAL 0 ILVD1 -1.0000000 OMVAL -1.0000000 GLU +1.0000000 AKG +1.0000000 ILE 0 ILVE1R -2.0000000 PYR +1.0000000 CO2 +1.0000000 ACLAC 0 ILVB2 -2.0000000 PYR +1.0000000 CO2 +1.0000000 ACLAC 0 ILVG2 -2.0000000 PYR +1.0000000 CO2 +1.0000000 ACLAC 0 ILVI2 -1.0000000 ACLAC -1.0000000 NADPH +1.0000000 NADP +1.0000000 DHVAL 0 ILVC2 -1.0000000 DHVAL +1.0000000 OIVAL 0 ILVD2 -1.0000000 OIVAL -1.0000000 GLU +1.0000000 AKG +1.0000000 VAL 0 ILVE2 -1.0000000 OIVAL -1.0000000 ALA +1.0000000 PYR +1.0000000 VAL 0 AVTA2 -1.0000000 ACCOA -1.0000000 OIVAL +1.0000000 COA +1.0000000 CBHCAP 0 LEUA -1.0000000 CBHCAP +1.0000000 IPPMAL 0 LEUCR -1.0000000 IPPMAL -1.0000000 NAD +1.0000000 NADH +1.0000000 OICAP +1.0000000 CO2 0 LEUB -1.0000000 OICAP -1.0000000 GLU +1.0000000 AKG +1.0000000 LEU 0 ILVE4 -1.0000000 OICAP -1.0000000 GLU +1.0000000 AKG +1.0000000 LEU 0 TYRB -1.0000000 E4P -1.0000000 PEP +1.0000000 PI +1.0000000 3DDAH7P 0 AROF -1.0000000 E4P -1.0000000 PEP +1.0000000 PI +1.0000000 3DDAH7P 0 AROG -1.0000000 E4P -1.0000000 PEP +1.0000000 PI +1.0000000 3DDAH7P 0 AROH -1.0000000 3DDAH7P +1.0000000 DQT +1.0000000 PI 0 AROB -1.0000000 DQT +1.0000000 DHSK 0 ARODR -1.0000000 DHSK -1.0000000 NADPH +1.0000000 SME +1.0000000 NADP 0 AROER -1.0000000 SME -1.0000000 ATP +1.0000000 ADP +1.0000000 SME5P 0 AROK -1.0000000 SME -1.0000000 ATP +1.0000000 ADP +1.0000000 SME5P 0 AROL -1.0000000 SME5P -1.0000000 PEP +1.0000000 3PSME +1.0000000 PI 0 AROAR -1.0000000 3PSME +1.0000000 PI +1.0000000 CHOR 0 AROC -1.0000000 CHOR +1.0000000 PHEN 0 PHEA1 -1.0000000 PHEN +1.0000000 CO2 +1.0000000 PHPYR 0 PHEA2 -1.0000000 PHPYR -1.0000000 GLU +1.0000000 AKG +1.0000000 PHE 0 TYRB1R -1.0000000 CHOR +1.0000000 PHEN 0 TYRA1 -1.0000000 PHEN -1.0000000 NAD +1.0000000 HPHPYR +1.0000000 CO2 +1.0000000 NADH 0 TYRA2 -1.0000000 HPHPYR -1.0000000 GLU +1.0000000 AKG +1.0000000 TYR 0 TYRB2R -1.0000000 HPHPYR -1.0000000 GLU +1.0000000 AKG +1.0000000 TYR 0 ASPC2R -1.0000000 CHOR -1.0000000 GLN +1.0000000 GLU +1.0000000 PYR +1.0000000 AN 0 TRPDE -1.0000000 AN -1.0000000 PRPP +1.0000000 PPI +1.0000000 NPRAN 0 TRPD -1.0000000 NPRAN +1.0000000 CPAD5P 0 TRPC1 -1.0000000 CPAD5P +1.0000000 CO2 +1.0000000 IGP 0 TRPC2 -1.0000000 IGP -1.0000000 SER +1.0000000 T3P1 +1.0000000 TRP 0 TRPA -1.0000000 R5P -1.0000000 ATP +1.0000000 PRPP +1.0000000 AMP 0 PRSAR -1.0000000 PRPP -1.0000000 ATP +1.0000000 PPI +1.0000000 PRBATP 0 HISG -1.0000000 PRBATP +1.0000000 PPI +1.0000000 PRBAMP 0 HISI1 -1.0000000 PRBAMP +1.0000000 PRFP 0 HISI2 -1.0000000 PRFP +1.0000000 PRLP 0 HISA -1.0000000 PRLP -1.0000000 GLN +1.0000000 GLU +1.0000000 AICAR +1.0000000 DIMGP 0 HISF -1.0000000 DIMGP +1.0000000 IMACP 0 HISB1 -1.0000000 IMACP -1.0000000 GLU +1.0000000 AKG +1.0000000 HISOLP 0 HISC -1.0000000 HISOLP +1.0000000 PI +1.0000000 HISOL 0 HISB2 -1.0000000 HISOL -3.0000000 NAD +1.0000000 HIS +3.0000000 NADH 0 HISD -1.0000000 3PG -1.0000000 NAD +1.0000000 NADH +1.0000000 PHP 0 SERA -1.0000000 PHP -1.0000000 GLU +1.0000000 AKG +1.0000000 3PSER 0 SERC1 -1.0000000 3PSER +1.0000000 PI +1.0000000 SER 0 SERB -1.0000000 THF -1.0000000 SER +1.0000000 GLY +1.0000000 METTHF 0 GLYA3 -1.0000000 THR -1.0000000 COA +1.0000000 GLY +1.0000000 ACCOA 0 TDH1 -1.0000000 THR -1.0000000 COA +1.0000000 GLY +1.0000000 ACCOA 0 KBL1 -1.0000000 SLF -1.0000000 ATP -1.0000000 GTP +1.0000000 PPI +1.0000000 APS +1.0000000 GDP +1.0000000 PI 0 CYSD -1.0000000 APS -1.0000000 ATP +1.0000000 ADP +1.0000000 PAPS 0 CYSC -1.0000000 PAPS -1.0000000 RTHIO +1.0000000 OTHIO +1.0000000 H2SO3 +1.0000000 PAP 0 CYSH -1.0000000 H2SO3 -3.0000000 NADPH +1.0000000 H2S +3.0000000 NADP 0 CYSIR -1.0000000 SER -1.0000000 ACCOA +1.0000000 COA +1.0000000 ASER 0 CYSER -1.0000000 ASER -1.0000000 H2S +1.0000000 AC +1.0000000 CYS 0 CYSK -1.0000000 ASER -1.0000000 H2S +1.0000000 AC +1.0000000 CYS 0 CYSM -1.0000000 PAP +1.0000000 AMP +1.0000000 PI 0 BISPHDS -1.0000000 ASP -1.0000000 ATP +1.0000000 ADP +1.0000000 BASP 0 THRA1R -1.0000000 ASP -1.0000000 ATP +1.0000000 ADP +1.0000000 BASP 0 METL1R -1.0000000 ASP -1.0000000 ATP +1.0000000 ADP +1.0000000 BASP 0 LYSCR -1.0000000 BASP -1.0000000 NADPH +1.0000000 NADP +1.0000000 PI +1.0000000 ASPSA 0 ASDR -1.0000000 ASPSA -1.0000000 NADPH +1.0000000 NADP +1.0000000 HSER 0 THRA2R -1.0000000 ASPSA -1.0000000 NADPH +1.0000000 NADP +1.0000000 HSER 0 METL2R -1.0000000 HSER -1.0000000 ATP +1.0000000 ADP +1.0000000 PHSER 0 THRB -1.0000000 PHSER +1.0000000 PI +1.0000000 THR 0 THRC1 -1.0000000 ASPSA -1.0000000 PYR +1.0000000 D23PIC 0 DAPA -1.0000000 D23PIC -1.0000000 NADPH +1.0000000 NADP +1.0000000 PIP26DX 0 DAPB -1.0000000 PIP26DX -1.0000000 SUCCOA +1.0000000 COA +1.0000000 NS2A6O 0 DAPD -1.0000000 NS2A6O -1.0000000 GLU +1.0000000 AKG +1.0000000 NS26DP 0 DAPCR -1.0000000 NS26DP +1.0000000 SUCC +1.0000000 D26PIM 0 DAPE -1.0000000 D26PIM +1.0000000 MDAP 0 DAPFR -1.0000000 MDAP +1.0000000 CO2 +1.0000000 LYS 0 LYSA -1.0000000 LYS +1.0000000 CO2 +1.0000000 CADV 0 CADA -1.0000000 LYS +1.0000000 CO2 +1.0000000 CADV 0 LDCC -1.0000000 HSER -1.0000000 SUCCOA +1.0000000 COA +1.0000000 OSLHSER 0 META -1.0000000 OSLHSER -1.0000000 CYS +1.0000000 SUCC +1.0000000 LLCT 0 METB1 -1.0000000 LLCT +1.0000000 HCYS +1.0000000 PYR +1.0000000 NH3 0 METC -1.0000000 HCYS -1.0000000 ADN +1.0000000 SAH 0 ADCSASER -1.0000000 HCYS -1.0000000 MTHF +1.0000000 MET +1.0000000 THF 0 METH -1.0000000 HCYS -1.0000000 MTHF +1.0000000 MET +1.0000000 THF 0 METE -1.0000000 MET -1.0000000 ATP +1.0000000 PPI +1.0000000 PI +1.0000000 SAM 0 METK -1.0000000 DALA -1.0000000 FAD +1.0000000 FADH +1.0000000 PYR +1.0000000 NH3 0 DADA -1.0000000 PTRC -1.0000000 AKG +1.0000000 GABAL +1.0000000 GLU 0 PAT -1.0000000 PTRC +1.0000000 GABAL +1.0000000 NH3 0 TYNA -1.0000000 GABAL -1.0000000 NAD +1.0000000 GABA +1.0000000 NADH 0 PRR_ -1.0000000 GABAL -1.0000000 NAD +1.0000000 GABA +1.0000000 NADH 0 ALDH3 -1.0000000 GABA -1.0000000 AKG +1.0000000 SUCCSAL +1.0000000 GLU 0 GABT -1.0000000 GABA -1.0000000 AKG +1.0000000 SUCCSAL +1.0000000 GLU 0 GOAG -1.0000000 SUCCSAL -1.0000000 NAD +1.0000000 SUCC +1.0000000 NADH 0 SAD -1.0000000 SUCCSAL -1.0000000 NADP +1.0000000 SUCC +1.0000000 NADPH 0 GABD -1.0000000 ASN +1.0000000 ASP +1.0000000 NH3 0 ASNA2 -1.0000000 ASN +1.0000000 ASP +1.0000000 NH3 0 ASNB2 -1.0000000 ASP +1.0000000 FUM +1.0000000 NH3 0 ASPA -1.0000000 CYS +1.0000000 PYR +1.0000000 NH3 +1.0000000 H2S 0 TNAA1 -1.0000000 CYS +1.0000000 PYR +1.0000000 NH3 +1.0000000 H2S 0 CYSDFSE -1.0000000 GLU +1.0000000 GABA +1.0000000 CO2 0 GADA -1.0000000 GLU +1.0000000 GABA +1.0000000 CO2 0 GADB -1.0000000 GLN +1.0000000 GLU +1.0000000 NH3 0 GLNASEA -1.0000000 GLN +1.0000000 GLU +1.0000000 NH3 0 GLNASEB -1.0000000 PRO -1.0000000 FAD +1.0000000 FADH +1.0000000 GLUGSAL 0 PUTA1 -1.0000000 GLUGSAL -1.0000000 NAD +1.0000000 NADH +1.0000000 GLU 0 PUTA2 -1.0000000 SER +1.0000000 PYR +1.0000000 NH3 0 SDAA1 -1.0000000 SER +1.0000000 PYR +1.0000000 NH3 0 SDAB1 -1.0000000 SER +1.0000000 PYR +1.0000000 NH3 0 TNAA2 -1.0000000 DSER +1.0000000 PYR +1.0000000 NH3 0 DSDA -1.0000000 THR -1.0000000 NAD +1.0000000 2A3O +1.0000000 NADH 0 TDH2 -1.0000000 2A3O -1.0000000 COA +1.0000000 ACCOA +1.0000000 GLY 0 KBL2 -1.0000000 THR +1.0000000 OBUT +1.0000000 NH3 0 TDCB2 -1.0000000 THR +1.0000000 OBUT +1.0000000 NH3 0 SDAA2 -1.0000000 THR +1.0000000 OBUT +1.0000000 NH3 0 SDAB2 -1.0000000 TRP +1.0000000 INDOLE +1.0000000 PYR +1.0000000 NH3 0 TNAA3R -1.0000000 PRPP -1.0000000 GLN +1.0000000 PPI +1.0000000 GLU +1.0000000 PRAM 0 PURF -1.0000000 PRAM -1.0000000 ATP -1.0000000 GLY +1.0000000 ADP +1.0000000 PI +1.0000000 GAR 0 PURDR -1.0000000 GAR -1.0000000 FTHF +1.0000000 THF +1.0000000 FGAR 0 PURN -1.0000000 GAR -1.0000000 FOR -1.0000000 ATP +1.0000000 ADP +1.0000000 PI +1.0000000 FGAR 0 PURT2 -1.0000000 FGAR -1.0000000 ATP -1.0000000 GLN +1.0000000 GLU +1.0000000 ADP +1.0000000 PI +1.0000000 FGAM 0 PURL -1.0000000 FGAM -1.0000000 ATP +1.0000000 ADP +1.0000000 PI +1.0000000 AIR 0 PURM -1.0000000 AIR -1.0000000 CO2 -1.0000000 ATP +1.0000000 NCAIR +1.0000000 ADP +1.0000000 PI 0 PURKR -1.0000000 NCAIR +1.0000000 CAIR 0 PURER -1.0000000 CAIR -1.0000000 ATP -1.0000000 ASP +1.0000000 ADP +1.0000000 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0 XAPA2R -1.0000000 DA -1.0000000 PI +1.0000000 AD +1.0000000 DR1P 0 DEOD2R -1.0000000 DG -1.0000000 PI +1.0000000 GN +1.0000000 DR1P 0 XAPA3R -1.0000000 DG -1.0000000 PI +1.0000000 GN +1.0000000 DR1P 0 DEOD3R -1.0000000 HYXN -1.0000000 R1P +1.0000000 INS +1.0000000 PI 0 XAPA4R -1.0000000 HYXN -1.0000000 R1P +1.0000000 INS +1.0000000 PI 0 DEOD4R -1.0000000 AD -1.0000000 R1P +1.0000000 PI +1.0000000 ADN 0 XAPA5R -1.0000000 AD -1.0000000 R1P +1.0000000 PI +1.0000000 ADN 0 DEOD5R -1.0000000 GN -1.0000000 R1P +1.0000000 PI +1.0000000 GSN 0 XAPA6R -1.0000000 GN -1.0000000 R1P +1.0000000 PI +1.0000000 GSN 0 DEOD6R -1.0000000 XAN -1.0000000 R1P +1.0000000 PI +1.0000000 XTSN 0 XAPA7R -1.0000000 XAN -1.0000000 R1P +1.0000000 PI +1.0000000 XTSN 0 DEOD7R -1.0000000 URI -1.0000000 PI +1.0000000 URA +1.0000000 R1P 0 UDPR -1.0000000 DU -1.0000000 PI +1.0000000 URA +1.0000000 DR1P 0 DEOA1R -1.0000000 DU -1.0000000 PI +1.0000000 URA +1.0000000 DR1P 0 DEOD8R -1.0000000 DT -1.0000000 PI +1.0000000 THY 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-1.0000000 C140 -1.0000000 ATP -7.0000000 COA -7.0000000 FAD -7.0000000 NAD +1.0000000 AMP +1.0000000 PPI +7.0000000 FADH +7.0000000 NADH +7.0000000 ACCOA 0 C140DG -1.0000000 C160 -1.0000000 ATP -8.0000000 COA -8.0000000 FAD -8.0000000 NAD +1.0000000 AMP +1.0000000 PPI +8.0000000 FADH +8.0000000 NADH +8.0000000 ACCOA 0 C160DG -1.0000000 C180 -1.0000000 ATP -9.0000000 COA -9.0000000 FAD -9.0000000 NAD +1.0000000 AMP +1.0000000 PPI +9.0000000 FADH +9.0000000 NADH +9.0000000 ACCOA 0 C180DG -1.0000000 T3P1 -1.0000000 PYR -2.0000000 NADPH -1.0000000 ATP +1.0000000 IPPP +1.0000000 ADP +2.0000000 NADP +1.0000000 CO2 0 IPPPSYN -1.0000000 IPPP +1.0000000 DMPP 0 IPPPISO -1.0000000 DMPP -1.0000000 IPPP +1.0000000 GPP +1.0000000 PPI 0 ISPA1 -1.0000000 GPP -1.0000000 IPPP +1.0000000 FPP +1.0000000 PPI 0 ISPA2 -5.0000000 IPPP -1.0000000 FPP +1.0000000 OPP +5.0000000 PPI 0 ISPB -8.0000000 IPPP -1.0000000 FPP +1.0000000 UDPP +8.0000000 PPI 0 UDPPSYN -1.0000000 CHOR +1.0000000 4HBZ +1.0000000 PYR 0 UBIC -1.0000000 4HBZ -1.0000000 OPP +1.0000000 O4HBZ +1.0000000 PPI 0 UBIA -1.0000000 O4HBZ +1.0000000 CO2 +1.0000000 2OPPP 0 UBID -1.0000000 2OPPP -1.0000000 O2 +1.0000000 2O6H 0 UBIB -1.0000000 2O6H -1.0000000 SAM +1.0000000 2OPMP +1.0000000 SAH 0 METHRXN -1.0000000 2OPMP -1.0000000 O2 +1.0000000 2OPMB 0 UBIH -1.0000000 2OPMB -1.0000000 SAM +1.0000000 2OPMMB +1.0000000 SAH 0 UBIE -1.0000000 2OPMMB -1.0000000 O2 +1.0000000 2OMHMB 0 UBIF -1.0000000 2OMHMB -1.0000000 SAM +1.0000000 QH2 +1.0000000 SAH 0 UBIG -1.0000000 CHOR +1.0000000 ICHOR 0 MENF -1.0000000 AKG -1.0000000 TPP +1.0000000 SSALTPP +1.0000000 CO2 0 MEND1 -1.0000000 ICHOR -1.0000000 SSALTPP +1.0000000 PYR +1.0000000 TPP +1.0000000 SHCHC 0 MEND2 -1.0000000 SHCHC +1.0000000 OSB 0 MENC -1.0000000 OSB -1.0000000 ATP -1.0000000 COA +1.0000000 OSBCOA +1.0000000 AMP +1.0000000 PPI 0 MENE -1.0000000 OSBCOA +1.0000000 DHNA +1.0000000 COA 0 MENB -1.0000000 DHNA -1.0000000 OPP +1.0000000 DMK +1.0000000 PPI +1.0000000 CO2 0 MENA 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bALA 0 PAND -1.0000000 PANT -1.0000000 bALA -1.0000000 ATP +1.0000000 AMP +1.0000000 PPI +1.0000000 PNTO 0 PANC -1.0000000 PNTO -1.0000000 ATP +1.0000000 ADP +1.0000000 4PPNTO 0 COAA -1.0000000 4PPNTO -1.0000000 CTP -1.0000000 CYS +1.0000000 CMP +1.0000000 PPI +1.0000000 4PPNCYS 0 PCLIG -1.0000000 4PPNCYS +1.0000000 CO2 +1.0000000 4PPNTE 0 PCDCL -1.0000000 4PPNTE -1.0000000 ATP +1.0000000 PPI +1.0000000 DPCOA 0 PATRAN -1.0000000 DPCOA -1.0000000 ATP +1.0000000 ADP +1.0000000 COA 0 DPHCOAK -1.0000000 COA +1.0000000 PAP +1.0000000 ACP 0 ACPS -1.0000000 ASP -1.0000000 FAD +1.0000000 FADH +1.0000000 ISUCC 0 NADB -1.0000000 ISUCC -1.0000000 T3P2 +1.0000000 PI +1.0000000 QA 0 NADA -1.0000000 QA -1.0000000 PRPP +1.0000000 NAMN +1.0000000 CO2 +1.0000000 PPI 0 NADC -1.0000000 NAMN -1.0000000 ATP +1.0000000 PPI +1.0000000 NAAD 0 NADD1 -1.0000000 NMN -1.0000000 ATP +1.0000000 NAD +1.0000000 PPI 0 NADD2 -1.0000000 NAAD -1.0000000 ATP -1.0000000 NH3 +1.0000000 NAD +1.0000000 AMP +1.0000000 PPI 0 NADE -1.0000000 NAD -1.0000000 ATP +1.0000000 NADP +1.0000000 ADP 0 NADF -1.0000000 NADP +1.0000000 NAD +1.0000000 PI 0 NADPHPS -1.0000000 NAD +1.0000000 NMN +1.0000000 AMP 0 LIG -1.0000000 NMN +1.0000000 NAMN +1.0000000 NH3 0 PNCC -1.0000000 NMN +1.0000000 R5P +1.0000000 NAm 0 NMNGLH -1.0000000 NAm +1.0000000 NA +1.0000000 NH3 0 PNCA -1.0000000 NA -1.0000000 PRPP -1.0000000 ATP +1.0000000 NAMN +1.0000000 PPI +1.0000000 PI +1.0000000 ADP 0 PNCB -1.0000000 NADxt +1.0000000 NMNxt +1.0000000 AMPxt 0 PNUE -1.0000000 NMNxt +1.0000000 NMN 0 PNUC -1.0000000 NMNxt +1.0000000 R5P +1.0000000 NAm 0 NMNUP2 -1.0000000 NAxt +1.0000000 NA 0 NAUP -1.0000000 GLU -1.0000000 ATP +1.0000000 GTRNA +1.0000000 AMP +1.0000000 PPI 0 HEMM -1.0000000 GLU -1.0000000 ATP +1.0000000 GTRNA +1.0000000 AMP +1.0000000 PPI 0 GLTX -1.0000000 GTRNA -1.0000000 NADPH +1.0000000 GSA +1.0000000 NADP 0 HEMA -1.0000000 GSA +1.0000000 ALAV 0 HEML -8.0000000 ALAV +4.0000000 PBG 0 HEMB -4.0000000 PBG +1.0000000 HMB +4.0000000 NH3 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GC -1.0000000 ATP +1.0000000 RGT +1.0000000 PI +1.0000000 ADP 0 GSHB -1.0000000 NADPH -1.0000000 OGT +1.0000000 NADP +1.0000000 RGT 0 GOR_R -1.0000000 AIR +1.0000000 AHM 0 THIC -1.0000000 AHM -1.0000000 ATP +1.0000000 AHMP +1.0000000 ADP 0 THIN -1.0000000 AHMP -1.0000000 ATP +1.0000000 AHMPP +1.0000000 ADP 0 THID -1.0000000 T3P1 -1.0000000 PYR +1.0000000 DTP 0 UNKRXN1 -1.0000000 DTP -1.0000000 TYR -1.0000000 CYS +1.0000000 THZ +1.0000000 HBA +1.0000000 CO2 0 THIG -1.0000000 DTP -1.0000000 TYR -1.0000000 CYS +1.0000000 THZ +1.0000000 HBA +1.0000000 CO2 0 THIE -1.0000000 DTP -1.0000000 TYR -1.0000000 CYS +1.0000000 THZ +1.0000000 HBA +1.0000000 CO2 0 THIF -1.0000000 DTP -1.0000000 TYR -1.0000000 CYS +1.0000000 THZ +1.0000000 HBA +1.0000000 CO2 0 THIH -1.0000000 THZ -1.0000000 ATP +1.0000000 THZP +1.0000000 ADP 0 THIM -1.0000000 THZP -1.0000000 AHMPP +1.0000000 THMP +1.0000000 PPI 0 THIB -1.0000000 THMP -1.0000000 ADP +1.0000000 THIAMIN +1.0000000 ATP 0 THIKR -1.0000000 THMP -1.0000000 ATP +1.0000000 TPP +1.0000000 ADP 0 THILR -1.0000000 E4P -1.0000000 NAD +1.0000000 ER4P +1.0000000 NADH 0 EPDR -1.0000000 ER4P -1.0000000 NAD +1.0000000 OHB +1.0000000 NADH 0 PDXBR -1.0000000 OHB -1.0000000 GLU +1.0000000 PHT +1.0000000 AKG 0 SERC2R -1.0000000 PHT -1.0000000 DX5P +1.0000000 P5P +1.0000000 CO2 0 PDXA -1.0000000 P5P -1.0000000 O2 +1.0000000 PL5P +1.0000000 H2O2 0 PDXHR -1.0000000 PHT +1.0000000 4HLT +1.0000000 PI 0 THRC2 -1.0000000 4HLT +1.0000000 PYRDX 0 UNKRXN3 -1.0000000 PYRDX -1.0000000 ATP +1.0000000 P5P +1.0000000 ADP 0 PDXK1 -1.0000000 P5P +1.0000000 PYRDX +1.0000000 PI 0 UNKRXN4 -1.0000000 PL5P +1.0000000 PL +1.0000000 PI 0 UNKRXN5 -1.0000000 PL -1.0000000 ATP +1.0000000 PL5P +1.0000000 ADP 0 PDXK2 -1.0000000 PYRDX -1.0000000 O2 +1.0000000 PL +1.0000000 H2O2 0 PDXH1R -1.0000000 PL -1.0000000 O2 -1.0000000 NH3 +1.0000000 PDLA +1.0000000 H2O2 0 PDXH2R -1.0000000 PDLA -1.0000000 ATP +1.0000000 PDLA5P +1.0000000 ADP 0 PDXK3 -1.0000000 PDLA5P +1.0000000 PDLA +1.0000000 PI 0 UNKRXN6 -1.0000000 PDLA5P -1.0000000 O2 +1.0000000 PL5P +1.0000000 H202 +1.0000000 NH3 0 PDXH3 -1.0000000 PL5P -1.0000000 GLU +1.0000000 PDLA5P +1.0000000 AKG 0 GLYA1 -1.0000000 PL5P -1.0000000 ALA +1.0000000 PDLA5P +1.0000000 PYR 0 GLYA2 -1.0000000 F6P -1.0000000 GLN +1.0000000 GLU +1.0000000 GA6P 0 GLMS -1.0000000 GA6P +1.0000000 GA1P 0 GLMMR -1.0000000 UTP -1.0000000 GA1P -1.0000000 ACCOA +1.0000000 UDPNAG +1.0000000 PPI +1.0000000 COA 0 GLMU -1.0000000 C140ACP -1.0000000 UDPNAG +1.0000000 ACP +1.0000000 UDPG2AA 0 LPXA -1.0000000 UDPG2AA +1.0000000 UDPG2A +1.0000000 AC 0 LPXC -1.0000000 UDPG2A -1.0000000 C140ACP +1.0000000 ACP +1.0000000 UDPG23A 0 LPXD -1.0000000 UDPG23A +1.0000000 UMP +1.0000000 LIPX 0 USHA -1.0000000 LIPX -1.0000000 UDPG23A +1.0000000 UDP +1.0000000 DISAC1P 0 LPXB -1.0000000 DISAC1P -1.0000000 ATP +1.0000000 ADP +1.0000000 LIPIV 0 TCDSK -1.0000000 LIPIV -1.0000000 CMPKDO +1.0000000 KDOLIPIV +1.0000000 CMP 0 KDTA1 -1.0000000 KDOLIPIV -1.0000000 CMPKDO +1.0000000 K2LIPIV +1.0000000 CMP 0 KDTA2 -1.0000000 K2LIPIV -1.0000000 C140ACP -1.0000000 C120ACP +1.0000000 LIPA +2.0000000 ACP 0 HTRB -1.0000000 PEP -1.0000000 A5P +1.0000000 KDOP +1.0000000 PI 0 KDSA -1.0000000 KDOP +1.0000000 KDO +1.0000000 PI 0 KDOPH -1.0000000 KDO -1.0000000 CTP +1.0000000 PPI +1.0000000 CMPKDO 0 KDSB -1.0000000 S7P -1.0000000 ATP +1.0000000 ADPHEP +1.0000000 PPI 0 LPCA -1.0000000 G1P -1.0000000 UTP +1.0000000 PPI +1.0000000 UDPG 0 GALU2 -1.0000000 PE -1.0000000 CMP +1.0000000 CDPETN +1.0000000 DGR 0 ETHAPHTR -1.0000000 PA +1.0000000 PI +1.0000000 DGR 0 PAPHTSE -1.0000000 DGR -1.0000000 ATP +1.0000000 ADP +1.0000000 PA 0 DAGKIN -1.0000000 LIPA -3.0000000 ADPHEP -2.0000000 UDPG -2.0000000 CDPETN -3.0000000 CMPKDO +1.0000000 LPS +3.0000000 ADP +2.0000000 UDP +3.0000000 CMP +2.0000000 CDP 0 RFAL -1.0000000 UDPNAG -1.0000000 PEP +1.0000000 UDPNAGEP +1.0000000 PI 0 MURA -1.0000000 UDPNAGEP -1.0000000 NADPH +1.0000000 UDPNAM +1.0000000 NADP 0 MURB -1.0000000 UDPNAM -1.0000000 ALA -1.0000000 ATP +1.0000000 ADP +1.0000000 PI +1.0000000 UDPNAMA 0 MURC -1.0000000 UDPNAMA -1.0000000 DGLU -1.0000000 ATP +1.0000000 UDPNAMAG +1.0000000 ADP +1.0000000 PI 0 MURD -1.0000000 UDPNAMAG -1.0000000 ATP -1.0000000 MDAP +1.0000000 UNAGD +1.0000000 ADP +1.0000000 PI 0 MURE -1.0000000 UNAGD -1.0000000 ATP -1.0000000 AA +1.0000000 UNAGDA +1.0000000 ADP +1.0000000 PI 0 MURF -1.0000000 GLU +1.0000000 DGLU 0 MURIR -2.0000000 DALA +1.0000000 AA 0 DDLAR -1.0000000 UNAGDA +1.0000000 UMP +1.0000000 PI +1.0000000 UNPTDO 0 MRAY -1.0000000 UNPTDO -1.0000000 UDPNAG +1.0000000 UDP +1.0000000 PEPTIDO 0 MURG -0.4880000 ALA -0.2810000 ARG -0.2290000 ASP -0.2290000 ASN -0.0870000 CYS -0.2500000 GLU -0.2500000 GLN -0.5820000 GLY -0.0900000 HIS -0.2760000 ILE -0.4280000 LEU -0.3260000 LYS -0.1460000 MET -0.1760000 PHE -0.2100000 PRO -0.2050000 SER -0.2410000 THR -0.0540000 TRP -0.1310000 TYR -0.4020000 VAL -0.0276000 PEPTIDO -0.0084000 LPS -0.0025800 PS -0.0967500 PE -0.0064500 CL -0.0232200 PG -0.0247000 DATP -0.0254000 DGTP -0.0254000 DCTP -0.0247000 DTTP -0.2030000 GTP -0.1260000 CTP -0.1360000 UTP -0.1540000 GLYCOGEN -0.0500000 MTHF -0.0021500 NAD -0.0000500 NADH -0.0001300 NADP -0.0004000 NADPH -0.0030000 UDPG -0.0000060 COA -0.0000500 ACCOA -0.0000030 SUCCOA -0.0000100 FAD -0.0070000 SPMD -0.0350000 PTRC -45.7318000 ATP -0.0010000 AMP +45.5608000 ADP +45.5628000 PI +0.7302000 PPI +1.000000 Biomass 0 VGRO -1.0000000 ARABxt -1.0000000 HEXT +1.0000000 ARAB 0 ARABUP1R -1.0000000 ARABxt -1.0000000 ATP +1.0000000 ARAB +1.0000000 ADP +1.0000000 PI 0 ARABUP2 -1.0000000 DHAxt -1.0000000 PEP +1.0000000 T3P2 +1.0000000 PYR 0 DHAPUP -1.0000000 FRUxt -1.0000000 PEP +1.0000000 F1P +1.0000000 PYR 0 FRUPTS -1.0000000 FUCxt -1.0000000 HEXT +1.0000000 FUC 0 FUCUPR -1.0000000 GLTLxt -1.0000000 PEP +1.0000000 GLTL1P +1.0000000 PYR 0 GLTLUP -1.0000000 GLACxt -1.0000000 HEXT +1.0000000 GLAC 0 GALUP1 -1.0000000 GLCxt -1.0000000 HEXT +1.0000000 GLC 0 GLCUP2 -1.0000000 GLACxt -1.0000000 ATP +1.0000000 GLAC +1.0000000 ADP +1.0000000 PI 0 GALUP2 -1.0000000 GLTxt -1.0000000 PEP +1.0000000 GLT6P +1.0000000 PYR 0 GLTUP -1.0000000 GLCNxt -1.0000000 ATP +1.0000000 GLCN +1.0000000 ADP +1.0000000 PI 0 GLCNUP -1.0000000 GLCxt -1.0000000 PEP +1.0000000 G6P +1.0000000 PYR 0 GLCPTS -1.0000000 GLxt +1.0000000 GL 0 GLUPR -1.0000000 LACxt -1.0000000 HEXT +1.0000000 LAC 0 LACUPR -1.0000000 MLTxt -1.0000000 PEP +1.0000000 MLT6P +1.0000000 PYR 0 MALUP1 -1.0000000 MNTxt -1.0000000 PEP +1.0000000 MNT6P +1.0000000 PYR 0 MNTUP -1.0000000 MANxt -1.0000000 PEP +1.0000000 MAN1P +1.0000000 PYR 0 MANNUP -1.0000000 MELIxt -1.0000000 HEXT +1.0000000 MELI 0 MELIUP -1.0000000 NAG -1.0000000 PEP +1.0000000 NAGP +1.0000000 PYR 0 NAGUP -1.0000000 RMNxt -1.0000000 ATP +1.0000000 RMN +1.0000000 ADP +1.0000000 PI 0 RMNUP -1.0000000 RIBxt -1.0000000 ATP +1.0000000 RIB +1.0000000 ADP +1.0000000 PI 0 RIBUP -1.0000000 SUCxt -1.0000000 PEP +1.0000000 SUC6P +1.0000000 PYR 0 SUCUP -1.0000000 TRExt -1.0000000 PEP +1.0000000 TRE6P +1.0000000 PYR 0 TREUP -1.0000000 XYLxt -1.0000000 HEXT +1.0000000 XYL 0 XYLUP1 -1.0000000 XYLxt -1.0000000 ATP +1.0000000 XYL +1.0000000 ADP +1.0000000 PI 0 XYLUP -1.0000000 ALAxt -1.0000000 ATP +1.0000000 ALA +1.0000000 ADP +1.0000000 PI 0 ALAUP -1.0000000 ARGxt -1.0000000 ATP +1.0000000 ARG +1.0000000 ADP +1.0000000 PI 0 ARGUP -1.0000000 ASNxt -1.0000000 HEXT +1.0000000 ASN 0 ASNUP1R -1.0000000 ASNxt -1.0000000 ATP +1.0000000 ASN +1.0000000 ADP +1.0000000 PI 0 ASNUP2 -1.0000000 ASPxt -1.0000000 HEXT +1.0000000 ASP 0 ASPUP1 -1.0000000 ASPxt -1.0000000 ATP +1.0000000 ASP +1.0000000 ADP +1.0000000 PI 0 ASPUP2 -1.0000000 BCAAxt -1.0000000 HEXT +1.0000000 BCAA 0 BCAAUP1R -1.0000000 CYSxt -1.0000000 ATP +1.0000000 CYS +1.0000000 ADP +1.0000000 PI 0 CYSUP -1.0000000 DALAxt -1.0000000 ATP +1.0000000 DALA +1.0000000 ADP +1.0000000 PI 0 DALAUP1 -1.0000000 DALAxt -1.0000000 HEXT +1.0000000 DALA 0 DALAUP2R -1.0000000 DSERxt -1.0000000 HEXT +1.0000000 DSER 0 DSERUPR -1.0000000 GLYxt -1.0000000 HEXT +1.0000000 GLY 0 GLYUP1R -1.0000000 MDAPxt -1.0000000 ATP +1.0000000 MDAP +1.0000000 ADP +1.0000000 PI 0 MDAPUP -1.0000000 GABAxt -1.0000000 ATP +1.0000000 GABA +1.0000000 ADP +1.0000000 PI 0 GABAUP -1.0000000 GLUxt -1.0000000 HEXT +1.0000000 GLU 0 GLUUP1R -1.0000000 GLUxt -1.0000000 HEXT +1.0000000 GLU 0 GLUUP2R -1.0000000 GLUxt -1.0000000 ATP +1.0000000 GLU +1.0000000 ADP +1.0000000 PI 0 GLUUP3 -1.0000000 GLNxt -1.0000000 ATP +1.0000000 GLN +1.0000000 ADP +1.0000000 PI 0 GLNUP -1.0000000 GLYxt -1.0000000 ATP +1.0000000 GLY +1.0000000 ADP +1.0000000 PI 0 GLYUP2 -1.0000000 HISxt -1.0000000 ATP +1.0000000 HIS +1.0000000 ADP +1.0000000 PI 0 HISUP -1.0000000 ILExt -1.0000000 ATP +1.0000000 ILE +1.0000000 ADP +1.0000000 PI 0 ILEUP -1.0000000 LEUxt -1.0000000 ATP +1.0000000 LEU +1.0000000 ADP +1.0000000 PI 0 LEUUP -1.0000000 LYSxt -1.0000000 HEXT +1.0000000 LYS 0 LYSUP1R -1.0000000 LYSxt -1.0000000 ATP +1.0000000 LYS +1.0000000 ADP +1.0000000 PI 0 LYSUP2 -1.0000000 LYSxt -1.0000000 ATP +1.0000000 LYS +1.0000000 ADP +1.0000000 PI 0 LYSUP3 -1.0000000 METxt -1.0000000 ATP +1.0000000 MET +1.0000000 ADP +1.0000000 PI 0 METUP -1.0000000 ORNxt -1.0000000 ATP +1.0000000 ORN +1.0000000 ADP +1.0000000 PI 0 ORNUP -1.0000000 PHExt -1.0000000 HEXT +1.0000000 PHE 0 PHEUPR -1.0000000 PROxt -1.0000000 HEXT +1.0000000 PRO 0 PROUPR -1.0000000 PROxt -1.0000000 ATP +1.0000000 PRO +1.0000000 ADP +1.0000000 PI 0 PROUP2 -1.0000000 PTRCxt -1.0000000 ATP +1.0000000 PTRC +1.0000000 ADP +1.0000000 PI 0 PTRSCUP -1.0000000 SERxt -1.0000000 HEXT +1.0000000 SER 0 SERUP1R -1.0000000 SERxt -1.0000000 ATP +1.0000000 SER +1.0000000 ADP +1.0000000 PI 0 SERUP2 -1.0000000 SPMDxt -1.0000000 ATP +1.0000000 SPMD +1.0000000 ADP +1.0000000 PI 0 SPMDUP1 -1.0000000 PTRCxt -1.0000000 ATP +1.0000000 PTRC +1.0000000 ADP +1.0000000 PI 0 SPRDUP2 -1.0000000 THRxt -1.0000000 ATP +1.0000000 THR +1.0000000 ADP +1.0000000 PI 0 THRUP1 -1.0000000 THRxt -1.0000000 HEXT +1.0000000 THR 0 THRUP2R -1.0000000 TRPxt -1.0000000 HEXT +1.0000000 TRP 0 TRPUPR -1.0000000 TYRxt -1.0000000 HEXT +1.0000000 TYR 0 TYRUPR -1.0000000 VALxt -1.0000000 ATP +1.0000000 VAL +1.0000000 ADP +1.0000000 PI 0 VALUP -1.0000000 DIPEPxt -1.0000000 ATP +1.0000000 DIPEP +1.0000000 ADP +1.0000000 PI 0 DPEPUP -1.0000000 OPEPxt -1.0000000 ATP +1.0000000 OPEP +1.0000000 ADP +1.0000000 PI 0 OPEPUP -1.0000000 PEPTxt -1.0000000 ATP +1.0000000 PEPT +1.0000000 ADP +1.0000000 PI 0 PEPUP -1.0000000 URAxt -1.0000000 HEXT +1.0000000 URA 0 URAUP -1.0000000 NMNxt -1.0000000 HEXT +1.0000000 NMN 0 NMNUP -1.0000000 CYTSxt -1.0000000 HEXT +1.0000000 CYTS 0 CYTSUP -1.0000000 ADxt -1.0000000 HEXT +1.0000000 AD 0 ADUP -1.0000000 GNxt +1.0000000 GN 0 GNUPR -1.0000000 HYXNxt +1.0000000 HYXN 0 HYXNUPR -1.0000000 XTSNxt +1.0000000 XTSN 0 XTSNUPR -1.0000000 XANxt +1.0000000 XAN 0 XANUPR -1.0000000 ADNxt -1.0000000 HEXT +1.0000000 ADN 0 NCGUP1 -1.0000000 GSNxt -1.0000000 HEXT +1.0000000 GSN 0 NCGUP2 -1.0000000 URIxt -1.0000000 HEXT +1.0000000 URI 0 NCGUP3 -1.0000000 CYTDxt -1.0000000 HEXT +1.0000000 CYTD 0 NCGUP4 -1.0000000 INSxt -1.0000000 HEXT +1.0000000 INS 0 NCGUP5 -1.0000000 XTSNxt -1.0000000 HEXT +1.0000000 XTSN 0 NCGUP6 -1.0000000 DTxt -1.0000000 HEXT +1.0000000 DT 0 NCGUP7 -1.0000000 DINxt -1.0000000 HEXT +1.0000000 DIN 0 NCGUP8 -1.0000000 DGxt -1.0000000 HEXT +1.0000000 DG 0 NCGUP9 -1.0000000 DAxt -1.0000000 HEXT +1.0000000 DA 0 NCGUP10 -1.0000000 DCxt -1.0000000 HEXT +1.0000000 DC 0 NCGUP11 -1.0000000 DUxt -1.0000000 HEXT +1.0000000 DU 0 NCGUP12 -1.0000000 ADNxt -1.0000000 HEXT +1.0000000 ADN 0 NCCUP1 -1.0000000 URIxt -1.0000000 HEXT +1.0000000 URI 0 NCCUP2 -1.0000000 CYTDxt -1.0000000 HEXT +1.0000000 CYTD 0 NCCUP3 -1.0000000 DTxt -1.0000000 HEXT +1.0000000 DT 0 NCCUP4 -1.0000000 DAxt -1.0000000 HEXT +1.0000000 DA 0 NCCUP5 -1.0000000 DCxt -1.0000000 HEXT +1.0000000 DC 0 NCCUP6 -1.0000000 DUxt -1.0000000 HEXT +1.0000000 DU 0 NCCUP7 -1.0000000 ADNxt -1.0000000 HEXT +1.0000000 ADN 0 NCUP1 -1.0000000 GSNxt -1.0000000 HEXT +1.0000000 GSN 0 NCUP2 -1.0000000 URIxt -1.0000000 HEXT +1.0000000 URI 0 NCUP3 -1.0000000 CYTDxt -1.0000000 HEXT +1.0000000 CYTD 0 NCUP4 -1.0000000 INSxt -1.0000000 HEXT +1.0000000 INS 0 NCUP5 -1.0000000 XTSNxt -1.0000000 HEXT +1.0000000 XTSN 0 NCUP6 -1.0000000 DTxt -1.0000000 HEXT +1.0000000 DT 0 NCUP7 -1.0000000 DINxt -1.0000000 HEXT +1.0000000 DIN 0 NCUP8 -1.0000000 DGxt -1.0000000 HEXT +1.0000000 DG 0 NCUP9 -1.0000000 DAxt -1.0000000 HEXT +1.0000000 DA 0 NCUP10 -1.0000000 DCxt -1.0000000 HEXT +1.0000000 DC 0 NCUP11 -1.0000000 DUxt -1.0000000 HEXT +1.0000000 DU 0 NCUP12 -1.0000000 ACxt -1.0000000 HEXT +1.0000000 AC 0 ACUPR -1.0000000 LACxt -1.0000000 HEXT +1.0000000 LAC 0 LACUP2R -1.0000000 FORxt +1.0000000 FOR 0 FORUPR -1.0000000 ETHxt -1.0000000 HEXT +1.0000000 ETH 0 ETHUPR -1.0000000 SUCCxt -1.0000000 HEXT +1.0000000 SUCC 0 SUCCUPR -1.0000000 NH3xt -1.0000000 HEXT +1.0000000 NH3 0 NH3UPR -1.0000000 Kxt -1.0000000 ATP +1.0000000 K +1.0000000 ADP +1.0000000 PI 0 POTUP1 -1.0000000 Kxt -1.0000000 HEXT +1.0000000 K 0 POTUP2R -1.0000000 SLFxt -1.0000000 ATP +1.0000000 SLF +1.0000000 ADP +1.0000000 PI 0 H2SO4UP -1.0000000 PIxt -1.0000000 ATP +1.0000000 ADP +2.0000000 PI 0 PIUP1 -1.0000000 PIxt -1.0000000 HEXT +1.0000000 PI 0 PIUP2R -1.0000000 GL3Pxt -1.0000000 PI +1.0000000 GL3P 0 GL3PUP -1.0000000 SUCCxt -1.0000000 HEXT +1.0000000 SUCC 0 SUCCUP2R -1.0000000 FUMxt -1.0000000 HEXT +1.0000000 FUM 0 FUMUPR -1.0000000 MALxt -1.0000000 HEXT +1.0000000 MAL 0 MALUP2R -1.0000000 ASPxt -1.0000000 HEXT +1.0000000 ASP 0 ASPUPR -1.0000000 C140xt +1.0000000 C140 0 FAUP1 -1.0000000 C160xt +1.0000000 C160 0 FAUP2 -1.0000000 C180xt +1.0000000 C180 0 FAUP3 -1.0000000 AKGxt -1.0000000 HEXT +1.0000000 AKG 0 AKGUPR -1.0000000 NAxt +1.0000000 NA +1.0000000 HEXT 0 NAUP1R -1.0000000 NAxt +1.0000000 NA +1.0000000 HEXT 0 NAUP2R -1.0000000 PNTOxt -1.0000000 HEXT +1.0000000 PNTO 0 PANTOUPR -1.0000000 SLAxt -1.0000000 ATP +1.0000000 SLA +1.0000000 ADP +1.0000000 PI 0 SIALAUP -1.0000000 O2xt +1.0000000 O2 0 O2TXR -1.0000000 CO2xt +1.0000000 CO2 0 CO2TXR -1.0000000 UREAxt -2.0000000 HEXT +1.0000000 UREA 0 UREATXR -1.0000000 ATP +1.0000000 ADP +1.0000000 PI 0 ATPM -1.0000000 GLALxt +1.0000000 GLAL 0 GLALTXR -1.0000000 ACALxt +1.0000000 ACAL 0 ACALTXR -1.0000000 NAD +1.0000000 NADH 0 FNADH -1.0000000 NADP +1.0000000 NADPH 0 FNADPH -1.0000000 ADP -1.0000000 PI +1.0000000 ATP 0 FATP -1.0000000 Biomass +1.0000000 BMxt 0 Growth +1 NADxt 0 NADxtI -1 NADxt 0 NADxtO +1 NMNxt 0 NMNxtI -1 NMNxt 0 NMNxtO +1 AMPxt 0 AMPxtI -1 AMPxt 0 AMPxtO +1 NAxt 0 NAxtI -1 NAxt 0 NAxtO +1 ARABxt 0 ARABxtI -1 ARABxt 0 ARABxtO +1 DHAxt 0 DHAxtI -1 DHAxt 0 DHAxtO +1 FRUxt 0 FRUxtI -1 FRUxt 0 FRUxtO +1 FUCxt 0 FUCxtI -1 FUCxt 0 FUCxtO +1 GLTLxt 0 GLTLxtI -1 GLTLxt 0 GLTLxtO +1 GLACxt 0 GLACxtI -1 GLACxt 0 GLACxtO +1 GLCxt 0 GLCxtI -1 GLCxt 0 GLCxtO +1 GLTxt 0 GLTxtI -1 GLTxt 0 GLTxtO +1 GLCNxt 0 GLCNxtI -1 GLCNxt 0 GLCNxtO +1 GLxt 0 GLxtI -1 GLxt 0 GLxtO +1 LACxt 0 LACxtI -1 LACxt 0 LACxtO +1 MLTxt 0 MLTxtI -1 MLTxt 0 MLTxtO +1 MNTxt 0 MNTxtI -1 MNTxt 0 MNTxtO +1 MANxt 0 MANxtI -1 MANxt 0 MANxtO +1 MELIxt 0 MELIxtI -1 MELIxt 0 MELIxtO +1 RMNxt 0 RMNxtI -1 RMNxt 0 RMNxtO +1 RIBxt 0 RIBxtI -1 RIBxt 0 RIBxtO +1 SUCxt 0 SUCxtI -1 SUCxt 0 SUCxtO +1 TRExt 0 TRExtI -1 TRExt 0 TRExtO +1 XYLxt 0 XYLxtI -1 XYLxt 0 XYLxtO +1 ALAxt 0 ALAxtI -1 ALAxt 0 ALAxtO +1 ARGxt 0 ARGxtI -1 ARGxt 0 ARGxtO +1 ASNxt 0 ASNxtI -1 ASNxt 0 ASNxtO +1 ASPxt 0 ASPxtI -1 ASPxt 0 ASPxtO +1 BCAAxt 0 BCAAxtI -1 BCAAxt 0 BCAAxtO +1 CYSxt 0 CYSxtI -1 CYSxt 0 CYSxtO +1 DALAxt 0 DALAxtI -1 DALAxt 0 DALAxtO +1 DSERxt 0 DSERxtI -1 DSERxt 0 DSERxtO +1 GLYxt 0 GLYxtI -1 GLYxt 0 GLYxtO +1 MDAPxt 0 MDAPxtI -1 MDAPxt 0 MDAPxtO +1 GABAxt 0 GABAxtI -1 GABAxt 0 GABAxtO +1 GLUxt 0 GLUxtI -1 GLUxt 0 GLUxtO +1 GLNxt 0 GLNxtI -1 GLNxt 0 GLNxtO +1 HISxt 0 HISxtI -1 HISxt 0 HISxtO +1 ILExt 0 ILExtI -1 ILExt 0 ILExtO +1 LEUxt 0 LEUxtI -1 LEUxt 0 LEUxtO +1 LYSxt 0 LYSxtI -1 LYSxt 0 LYSxtO +1 METxt 0 METxtI -1 METxt 0 METxtO +1 ORNxt 0 ORNxtI -1 ORNxt 0 ORNxtO +1 PHExt 0 PHExtI -1 PHExt 0 PHExtO +1 PROxt 0 PROxtI -1 PROxt 0 PROxtO +1 PTRCxt 0 PTRCxtI -1 PTRCxt 0 PTRCxtO +1 SERxt 0 SERxtI -1 SERxt 0 SERxtO +1 SPMDxt 0 SPMDxtI -1 SPMDxt 0 SPMDxtO +1 THRxt 0 THRxtI -1 THRxt 0 THRxtO +1 TRPxt 0 TRPxtI -1 TRPxt 0 TRPxtO +1 TYRxt 0 TYRxtI -1 TYRxt 0 TYRxtO +1 VALxt 0 VALxtI -1 VALxt 0 VALxtO +1 DIPEPxt 0 DIPEPxtI -1 DIPEPxt 0 DIPEPxtO +1 OPEPxt 0 OPEPxtI -1 OPEPxt 0 OPEPxtO +1 PEPTxt 0 PEPTxtI -1 PEPTxt 0 PEPTxtO +1 URAxt 0 URAxtI -1 URAxt 0 URAxtO +1 CYTSxt 0 CYTSxtI -1 CYTSxt 0 CYTSxtO +1 ADxt 0 ADxtI -1 ADxt 0 ADxtO +1 GNxt 0 GNxtI -1 GNxt 0 GNxtO +1 HYXNxt 0 HYXNxtI -1 HYXNxt 0 HYXNxtO +1 XTSNxt 0 XTSNxtI -1 XTSNxt 0 XTSNxtO +1 XANxt 0 XANxtI -1 XANxt 0 XANxtO +1 ADNxt 0 ADNxtI -1 ADNxt 0 ADNxtO +1 GSNxt 0 GSNxtI -1 GSNxt 0 GSNxtO +1 URIxt 0 URIxtI -1 URIxt 0 URIxtO +1 CYTDxt 0 CYTDxtI -1 CYTDxt 0 CYTDxtO +1 INSxt 0 INSxtI -1 INSxt 0 INSxtO +1 DTxt 0 DTxtI -1 DTxt 0 DTxtO +1 DINxt 0 DINxtI -1 DINxt 0 DINxtO +1 DGxt 0 DGxtI -1 DGxt 0 DGxtO +1 DAxt 0 DAxtI -1 DAxt 0 DAxtO +1 DCxt 0 DCxtI -1 DCxt 0 DCxtO +1 DUxt 0 DUxtI -1 DUxt 0 DUxtO +1 ACxt 0 ACxtI -1 ACxt 0 ACxtO +1 FORxt 0 FORxtI -1 FORxt 0 FORxtO +1 ETHxt 0 ETHxtI -1 ETHxt 0 ETHxtO +1 SUCCxt 0 SUCCxtI -1 SUCCxt 0 SUCCxtO +1 NH3xt 0 NH3xtI -1 NH3xt 0 NH3xtO +1 Kxt 0 KxtI -1 Kxt 0 KxtO +1 SLFxt 0 SLFxtI -1 SLFxt 0 SLFxtO +1 PIxt 0 PIxtI -1 PIxt 0 PIxtO +1 GL3Pxt 0 GL3PxtI -1 GL3Pxt 0 GL3PxtO +1 FUMxt 0 FUMxtI -1 FUMxt 0 FUMxtO +1 MALxt 0 MALxtI -1 MALxt 0 MALxtO +1 C140xt 0 C140xtI -1 C140xt 0 C140xtO +1 C160xt 0 C160xtI -1 C160xt 0 C160xtO +1 C180xt 0 C180xtI -1 C180xt 0 C180xtO +1 AKGxt 0 AKGxtI -1 AKGxt 0 AKGxtO +1 PNTOxt 0 PNTOxtI -1 PNTOxt 0 PNTOxtO +1 SLAxt 0 SLAxtI -1 SLAxt 0 SLAxtO +1 O2xt 0 O2xtI -1 O2xt 0 O2xtO +1 CO2xt 0 CO2xtI -1 CO2xt 0 CO2xtO +1 UREAxt 0 UREAxtI -1 UREAxt 0 UREAxtO +1 GLALxt 0 GLALxtI -1 GLALxt 0 GLALxtO +1 ACALxt 0 ACALxtI -1 ACALxt 0 ACALxtO +1 PYR -1 HEXT -1 PYRxt 0 PYRUPR +1 PYRxt 0 PYRxtI -1 PYRxt 0 PYRxtO +1 BMxt 0 BMxtI -1 BMxt 0 BMxtO -1 ATP +1 ADP +1 PI 0 ATPMAX -1 NADH +1 NAD 0 NADHMAX -1 NADPH +1 NADP 0 NADPHMAX -1 G6P 0 G6PMAX -1 F6P 0 F6PMAX -1 R5P 0 R5PMAX -1 E4P 0 E4PMAX -1 T3P1 0 T3P1MAX -1 3PG 0 3PGMAX -1 PEP 0 PEPMAX -1 PYR 0 PYRMAX -1 ACCOA +1 COA 0 ACCOAMAX -1 OA 0 OAMAX -1 SUCCOA +1 COA 0 SUCAMAX -1 AKG 0 AKGMAX 0.0 end end E 0 max 1 Growth 0 end // ******************************************************************* // // ******************************************************************* // // This section defines that the metabolic flux constraints // // Growth Flux // 0 Growth 1000 // Non-growth associated Maintainance Requirements // 7.6 ATPM 7.6 // The fictitious reactions from above are set to zero // 0 FATP 0 0 FNADH 0 0 FNADPH 0 // *************************************************** // // *********** Oxygen ************ // // *************************************************** // // Oxygen Uptake // 10 O2xtI 10 0 O2xtO 0 // *************************************************** // // *********** Carbon Sources ************ // // *************************************************** // // Glucose // 0 GLCxtI 0 0 GLCxtO 1000 // Acetate // 10 ACxtI 10 0 ACxtO 0 // Pyruvate // 0 PYRxtI 0 0 PYRxtO 1000 // Glycerol // 0 GLxtI 0 0 GLxtO 1000 // Succinate // 0 SUCCxtI 0 0 SUCCxtO 1000 // Ribose // 0 RIBxtI 0 0 RIBxtO 1000 // *************************************************** // // ************* Carbon By- Products************* // // *************************************************** // // Formate Transport // 0 FORxtI 0 0 FORxtO 1000 // Ethanol Transport // 0 ETHxtI 0 0 ETHxtO 1000 // Carbon Dioxide Transport // 0 CO2xtI 1000 0 CO2xtO 1000 // Lactate Transport // 0 LACxtI 0 0 LACxtO 1000 // *************************************************** // // ************* Amino Acids ************* // // *************************************************** // // Glutamate // 0 GLUxtI 0 0 GLUxtO 1000 0 EDD 0 0 DEOC 0 0 ARADR 0 0 NADxtI 0 0 NADxtO 1000 0 NMNxtI 0 0 NMNxtO 1000 0 AMPxtI 0 0 AMPxtO 1000 0 NAxtI 0 0 NAxtO 1000 0 ARABxtI 0 0 ARABxtO 1000 0 DHAxtI 0 0 DHAxtO 1000 0 FRUxtI 0 0 FRUxtO 1000 0 FUCxtI 0 0 FUCxtO 1000 0 GLTLxtI 0 0 GLTLxtO 1000 0 GLACxtI 0 0 GLACxtO 1000 0 GLTxtI 0 0 GLTxtO 1000 0 GLCNxtI 0 0 GLCNxtO 1000 0 MLTxtI 0 0 MLTxtO 1000 0 MNTxtI 0 0 MNTxtO 1000 0 MANxtI 0 0 MANxtO 1000 0 MELIxtI 0 0 MELIxtO 1000 0 RMNxtI 0 0 RMNxtO 1000 0 SUCxtI 0 0 SUCxtO 1000 0 TRExtI 0 0 TRExtO 1000 0 XYLxtI 0 0 XYLxtO 1000 0 ALAxtI 0 0 ALAxtO 1000 0 ARGxtI 0 0 ARGxtO 1000 0 ASNxtI 0 0 ASNxtO 1000 0 ASPxtI 0 0 ASPxtO 1000 0 BCAAxtI 0 0 BCAAxtO 1000 0 CYSxtI 0 0 CYSxtO 1000 0 DALAxtI 0 0 DALAxtO 1000 0 DSERxtI 0 0 DSERxtO 1000 0 GLYxtI 0 0 GLYxtO 1000 0 MDAPxtI 0 0 MDAPxtO 1000 0 GABAxtI 0 0 GABAxtO 1000 0 GLNxtI 0 0 GLNxtO 1000 0 HISxtI 0 0 HISxtO 1000 0 ILExtI 0 0 ILExtO 1000 0 LEUxtI 0 0 LEUxtO 1000 0 LYSxtI 0 0 LYSxtO 1000 0 METxtI 0 0 METxtO 1000 0 ORNxtI 0 0 ORNxtO 1000 0 PHExtI 0 0 PHExtO 1000 0 PROxtI 0 0 PROxtO 1000 0 PTRCxtI 0 0 PTRCxtO 1000 0 SERxtI 0 0 SERxtO 1000 0 SPMDxtI 0 0 SPMDxtO 1000 0 THRxtI 0 0 THRxtO 1000 0 TRPxtI 0 0 TRPxtO 1000 0 TYRxtI 0 0 TYRxtO 1000 0 VALxtI 0 0 VALxtO 1000 0 DIPEPxtI 0 0 DIPEPxtO 1000 0 OPEPxtI 0 0 OPEPxtO 1000 0 PEPTxtI 0 0 PEPTxtO 1000 0 URAxtI 0 0 URAxtO 1000 0 CYTSxtI 0 0 CYTSxtO 1000 0 ADxtI 0 0 ADxtO 1000 0 GNxtI 0 0 GNxtO 1000 0 HYXNxtI 0 0 HYXNxtO 1000 0 XTSNxtI 0 0 XTSNxtO 1000 0 XANxtI 0 0 XANxtO 1000 0 ADNxtI 0 0 ADNxtO 1000 0 GSNxtI 0 0 GSNxtO 1000 0 URIxtI 0 0 URIxtO 1000 0 CYTDxtI 0 0 CYTDxtO 1000 0 INSxtI 0 0 INSxtO 1000 0 DTxtI 0 0 DTxtO 1000 0 DINxtI 0 0 DINxtO 1000 0 DGxtI 0 0 DGxtO 1000 0 DAxtI 0 0 DAxtO 1000 0 DCxtI 0 0 DCxtO 1000 0 DUxtI 0 0 DUxtO 1000 0 NH3xtI 1000 0 NH3xtO 1000 0 KxtI 1000 0 KxtO 1000 0 SLFxtI 1000 0 SLFxtO 1000 0 PIxtI 1000 0 PIxtO 1000 0 GL3PxtI 0 0 GL3PxtO 1000 0 FUMxtI 0 0 FUMxtO 1000 0 MALxtI 0 0 MALxtO 1000 0 C140xtI 0 0 C140xtO 1000 0 C160xtI 0 0 C160xtO 1000 0 C180xtI 0 0 C180xtO 1000 0 AKGxtI 0 0 AKGxtO 1000 0 PNTOxtI 0 0 PNTOxtO 1000 0 SLAxtI 0 0 SLAxtO 1000 0 UREAxtI 0 0 UREAxtO 1000 0 GLALxtI 0 0 GLALxtO 1000 0 ACALxtI 0 0 ACALxtO 1000 0 BMxtI 0 0 BMxtO 1000 0 end 0 rev. rxn 227 nonrev. rxn 518 total rxn 745 matrix columns 972 unique enzymes 570 Extra modifications of the the ATPase mutant. the flux distribution generated is equivalent. this is an example of alternate flux distributions 0 ATPAR 0 0 GLTA 100 0 PFLA 0 0 PFLC 100 0 PYROXRD 0 0 ACEA 0 0 AVTA1 0 0 GLPD 0 0 GLPA 0 0 LCTD 0 0 DLD2 0 0 DADA 0 0 ASPA 0 0 PUTA1 0 0 PNT1A 0 0 PNT2A 100 0 DEOC 0 The pyk mutant. There is only a minimal increase in the PPP flux, and the maeB, edd, and sfcA genes must be removed because they provide a negligable increase in growth. If the stoich of the pnt rxn is for 0 HEXT when converting NADPH to NADH. If the stoich is increased to just .25, the PPP flux increases about 30%. 0 PYKF 0 0 PYKA 0 0 EDD 0 0 MAEB 10 0 SFCA 10 0 DEOC 0 ace mutant adjustments 0 KBL2 0 0 TDH1 0 0 KBL1 0 0 PFLA 0 0 PFLC 0 0 POXB 0